1181 BACTERIAL ENDOTOXIN PROTECTION FROM PULMONARY OXYGEN TOXICITY
نویسندگان
چکیده
منابع مشابه
A Role for Phagocytes in Endotoxin Protection from Oxygen Toxicity
S OF PAPERS Eighth Annual Albert L. Tester Memorial Symposium
متن کاملThe role of endotoxin in protection of adult rats from oxygen-induced lung toxicity.
Adult rats show evidence of severe lung damage after 72h of continuous exposure to hyperoxia (96-98% O2). Treatment of adult rats with a solution of Plasmanate, inadvertently contaminated with endotoxin-producing organisms, or with purified endotoxin itself markedly altered the lung toxicity associated with hyperoxic exposure (survival in treated animals = 110/113 [97%] versus survival in untre...
متن کاملNormobaric Pulmonary Oxygen Toxicity
This study investigated the involvement of substances derived from arachidonic acid in the mechanism of endotoxin's protective action against pulmonary oxygen toxicity. Eighty-three percent of rats treated with a small dose of endotoxin (1 mgjkg) survived exposure to over 95% oxygen for 7 days. In contrast, all control rats exposed to the same oxygen concentration died within 3 days. When the e...
متن کاملSuperoxide dismutase and pulmonary oxygen toxicity.
The production of superoxide (O2-) under hyperoxic conditions is markedly accentuated leading to the generation of potent oxidants such as hydrogen peroxide (H2O2), hydroxyl radical (HO.), and peroxynitrite (ONOO-). Superoxide dismutase (SOD), by rapidly removing O2-, reduces the tissue concentration of O2- and prevents the production of HO. and ONOO-. Three forms of SOD exist in the lung: CuZn...
متن کاملPulmonary Oxygen Toxicity: Investigation and Mentoring
At sea level oxygen is toxic to man when breathed for more than twenty-four hours at a percentage greater than about forty percent. Pulmonary pathology is the first manifestation in subjects with previously normal lungs. In patients with pre-existing lung disease the results are often additive. There is, however, great variation in response from subject to subject and between patients. Queen's ...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1978
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-197804001-01187